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ÀåÀº°æ ( Jang Eun-Kyung ) - Severance Hospital Department of Neonatology Neonatal Intensive Care Unit
ÀÌÇýÁ¤ ( Lee Hye-Jung ) - Yonsei University College of Nursing Mo-Im Kim Nursing Research Institute ( Jo Keum-Sik ) - Severance Hospital Department of Neonatology Neonatal Intensive Care Unit À̼º¹Ì ( Lee Sung-Mi ) - Severance Hospital Department of Neonatology Neonatal Intensive Care Unit ¼ÇöÁø ( Seo Hyun-Jin ) - Severance Hospital Department of Neonatology Neonatal Intensive Care Unit ÇãÀºÁÖ ( Huh Eun-Joo ) - Severance Hospital Department of Neonatology Neonatal Intensive Care Unit
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Abstract
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Purpose: This study compared the pain-relieving effects of human milk, sucrose, and distilled water during examinations for retinopathy of prematurity.
Methods: Forty-five preterm infants were randomly assigned to receive a pacifier dipped in one of three solutions: human milk (n=14), 24% sucrose (n=15), or distilled water (n=16), 2 minutes before an eye examination. Their pain score, pulse rate, and oxygen saturation were measured at three time points: 5 minutes before the examination, 30 seconds after speculum introduction, and 2 minutes after the examination.
Results: The infants¡¯ mean gestational age and weight at birth were 33.1¡¾2.1 weeks and 1,842¡¾470 g, respectively. There were no between-group differences in pain relief during the eye examination. The pain score significantly increased both during (p<.001) and after the examinations (p=.003). Oxygen saturation decreased during the examinations (p<.001); however, the infants in the 24% sucrose group showed higher oxygen saturation (p=.047) during the examinations than the infants in the other groups.
Conclusion: Sucking on a pacifier dipped in human milk or 24% sucrose did not reduce the pain associated with eye examinations in preterm infants. Pacifiers dipped in sucrose can be used to maintain better oxygen saturation during these examinations.
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KeyWords
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Analgesia, Human milk, Pain, Retinopathy of prematurity, Sucrose
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